P2X4 receptor re-sensitization depends on a protonation/deprotonation cycle mediated by receptor internalization and recycling
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Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation.
Animal studies have shown that nicotine and psychostimulant drugs (amphetamine and cocaine) share the property of inducing long-lasting behavioral and neurochemical sensitization, which is thought to contribute to their addictive properties. Neuroplasticity subserving learning and memory mechanisms is considered to be involved in psychostimulant-induced sensitization and addiction behavior. Bec...
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It has been reported that ketamine as an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist has also non-NMDA receptor antagonist properties. We recently found that ketamine (20 ?M) affected differently induction of NMDA receptor-mediated long-term potentiation (LTP) when administered 30 min prior to tetanic Primed-Bursts (PBs) stimulation. On the other hand, ketamine also influenced...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2018
ISSN: 0022-3751
DOI: 10.1113/jp275448